Treatments

ED Treatments & Products

Explore established medications, compounded formulations, devices, supplements, imported products, and products with uncertain regulatory status.

Clinical profiles of established medications, medical devices, and other recognized erectile-dysfunction treatments. FDA-cleared devices are labeled as devices, not approved medications.

Evidence gradeSort

6 results

Other ED Treatment

Alprostadil Urethral Suppository

Alprostadil

B

Approved non-tablet option for people who cannot use PDE5 inhibitors.

FDA APPROVEDPRESCRIPTION
Type
Prescription intraurethral pellet
Regulatory
FDA Approved
Verification
Well Established
Editorial
Brief
Onset
5–10 min
Duration
30–60 min
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Prescription Medication

Avanafil

Avanafil

A

FDA-approved PDE5 inhibitor with a fast onset but less long-term real-world data.

FDA APPROVEDPRESCRIPTION
Type
Prescription PDE5 Inhibitor
Regulatory
FDA Approved
Verification
Well Established
Editorial
Reviewed
Onset
15–30 min
Duration
Up to 6 h
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Prescription Medication

Sildenafil

Sildenafil citrate

A

Well-established prescription PDE5 inhibitor with predictable on-demand use.

FDA APPROVEDPRESCRIPTION
Type
Prescription PDE5 Inhibitor
Regulatory
FDA Approved
Verification
Well Established
Editorial
Full Profile
Onset
30–60 min
Duration
4–6 h
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Prescription Medication

Tadalafil

Tadalafil

A

Long-duration PDE5 inhibitor with both daily and on-demand dosing options.

FDA APPROVEDPRESCRIPTION
Type
Prescription PDE5 Inhibitor
Regulatory
FDA Approved
Verification
Well Established
Editorial
Full Profile
Onset
30–120 min
Duration
Up to 36 h
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Device

Vacuum Erection Device

None (mechanical)

B

Drug-free mechanical option that avoids medication interactions.

FDA CLEARED
Type
Medical device
Regulatory
FDA Cleared Device
Verification
Well Established
Editorial
Brief
Onset
2–5 min
Duration
Up to 30 min (with ring)
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Prescription Medication

Vardenafil

Vardenafil hydrochloride

A

Established PDE5 inhibitor similar to sildenafil, with a distinctive QT-interval warning.

FDA APPROVEDPRESCRIPTION
Type
Prescription PDE5 Inhibitor
Regulatory
FDA Approved
Verification
Well Established
Editorial
Reviewed
Onset
25–60 min
Duration
4–5 h
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