Treatments · Compare

Compare ED Treatments

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Category
Treatment Type	Prescription PDE5 Inhibitor	Prescription PDE5 Inhibitor
Regulatory Status	FDA Approved	FDA Approved
Evidence Grade	AStrong Clinical Evidence	AStrong Clinical Evidence
Typical Onset	30–60 minutes	30 minutes to 2 hours
Duration	About 4–6 hours	Up to 36 hours
Food Considerations	High-fat meals can delay onset by about an hour	Minimal effect from food
Daily-Dosing Option	No / not established	Yes
Major Safety Issues	Organic nitrates / nitric oxide donors (e.g. nitroglycerin, isosorbide) Guanylate cyclase stimulators such as riociguat	Organic nitrates / nitric oxide donors (e.g. nitroglycerin, isosorbide) Guanylate cyclase stimulators such as riociguat
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SynMale does not declare a universal winner. Different medications may be appropriate for different patients depending on medical history, treatment goals, and clinician guidance.