02
What Is It?
A prescription product that delivers alprostadil locally, avoiding both tablets and needle injection.
Product Profile & Review
FDA APPROVEDPRESCRIPTION
Alprostadil Urethral Suppository
An FDA-approved non-oral option that delivers alprostadil via a small pellet into the urethra.
Also known as: MUSE (brand)
- Written by
- SynMale Editorial
- Originally Published
- October 2026
- Last Updated
- October 2026
- Medical Review
- Not yet independently reviewed
Executive Summary
- What is it?
- Prescription intraurethral pellet (Other ED Treatment).
- What does it contain or claim to contain?
- Alprostadil (verified)
- How well verified is this specific product?
- Well Established
- Most important thing to know
- Approved non-tablet option for people who cannot use PDE5 inhibitors.
B
Ingredient
Alprostadil
Product Type
Prescription intraurethral pellet
Regulatory Status
FDA Approved
Verification
Well Established
03
Claimed Active Ingredients
- VERIFIED INGREDIENTAlprostadil125–1000 mcg
A claimed ingredient is what a label or seller states. It is not treated as confirmed.
04
What Can We Verify?
Established
- FDA-approved with controlled-trial evidence.
Uncertain or unverified
- Efficacy is generally lower than injection.
05
How It Works
Alprostadil (prostaglandin E1) raises cAMP in smooth muscle, relaxing it and increasing blood flow independent of PDE5.
06
Evidence Level
BGood Supporting Evidence
Grades run from A (strong clinical evidence) to F (unsupported or contradicted). How we grade.
07
Clinical Profile
- Drug Class
- Prostaglandin E1 analogue
- Typical Onset
- About 5–10 minutes
- Effective Window
- About 30–60 minutes
- Typical Medical Dosing
- As prescribed
- Food Interaction
- None
- Daily vs On-Demand
- On-demand
08
Benefits / Potential Advantages
- Option for people who cannot take PDE5 inhibitors
- No needle
09
Limitations
- Lower success rates than injection
- Local discomfort is common
10
Side Effects & Precautions
Common effects
Penile or urethral pain, minor urethral bleeding, dizziness.
Major interactions & warnings
- • Priapism possible—seek care for erections over 4 hours.
- • Fainting and low blood pressure have been reported.
11
Regulatory Status
FDA ApprovedFDA Cleared DeviceNot FDA ApprovedDietary SupplementCompounded MedicationForeign-Market MedicationUnknownUnverified
FDA-approved prescription product.
Risk & Verification Summary
Evidence Grade
B — Good Supporting Evidence
Verification Level
Well Established
Regulatory Status
FDA Approved
Risk Level
Low
No numerical performance score is shown because reliable performance data does not exist for this product.
SynMale Verdict
LEGITIMATE
An approved, useful alternative for selected patients, though less effective than injections for many.
Bottom Line
What You Should Know
This is an approved non-tablet option. It can suit people who cannot use PDE5 inhibitors. It is generally less effective than injection and can cause local discomfort.