02
What Is It?
A supplement derived from the bark of an African tree. Its main compound, yohimbine, is an alpha-2 adrenergic blocker.
Product Profile & Review
SUPPLEMENT
Yohimbe
A bark extract containing yohimbine, a stimulant-like compound with significant cardiovascular side effects.
Also known as: Yohimbine, Pausinystalia johimbe
- Written by
- SynMale Editorial
- Originally Published
- October 2026
- Last Updated
- October 2026
- Medical Review
- Not yet independently reviewed
Executive Summary
- What is it?
- Herbal dietary supplement (Supplement).
- What does it contain or claim to contain?
- Yohimbine (claimed)
- How well verified is this specific product?
- Label Claims Often Inaccurate
- Most important thing to know
- Stimulant-like extract with cardiovascular side effects and frequently inaccurate labels.
D
Ingredient
Yohimbe bark extract (yohimbine)
Product Type
Herbal dietary supplement
Regulatory Status
Dietary Supplement
Verification
Label Claims Often Inaccurate
03
Claimed Active Ingredients
- CLAIMED INGREDIENTYohimbineFrequently mislabeled
A claimed ingredient is what a label or seller states. It is not treated as confirmed.
04
What Can We Verify?
Established
- Testing of commercial products has found yohimbine content often differs from label claims.
Uncertain or unverified
- Evidence for ED benefit is limited and older.
- Actual dose in a given product is often unknown.
05
How It Works
Yohimbine blocks alpha-2 receptors, increasing sympathetic (adrenaline-like) activity. This is not a PDE5 mechanism and brings cardiovascular effects.
06
Evidence Level
DWeak / Mostly Marketing Claims
Grades run from A (strong clinical evidence) to F (unsupported or contradicted). How we grade.
07
Clinical Profile
- Drug Class
- Alpha-2 adrenergic antagonist
- Typical Onset
- Cannot be reliably established
- Typical Medical Dosing
- No established safe supplement dose
08
Benefits / Potential Advantages
- Some limited older evidence of modest effect
09
Limitations
- Unreliable labeling
- Narrow safety margin
10
Side Effects & Precautions
Common effects
Anxiety, rapid heartbeat, raised blood pressure, tremor, insomnia.
Major interactions & warnings
- • Dangerous in people with heart disease, high blood pressure, anxiety disorders or on antidepressants.
- • Serious adverse events have been reported to poison centres.
11
Regulatory Status
FDA ApprovedFDA Cleared DeviceNot FDA ApprovedDietary SupplementCompounded MedicationForeign-Market MedicationUnknownUnverified
Sold as a supplement in the US; restricted or banned in some other countries.
12
Marketing Claims vs. Evidence
Claim
What the Evidence Shows
“Safe natural booster”
Yohimbine has significant cardiovascular risks.
Risk & Verification Summary
Evidence Grade
D — Weak / Mostly Marketing Claims
Verification Level
Label Claims Often Inaccurate
Regulatory Status
Dietary Supplement
Risk Level
High
No numerical performance score is shown because reliable performance data does not exist for this product.
SynMale Verdict
HIGH CAUTION
Weak evidence combined with real cardiovascular risk and unreliable labeling.
Bottom Line
What You Should Know
Yohimbe acts like a stimulant, not like ED medications. Labels are often inaccurate. It can raise heart rate and blood pressure. People with heart conditions should avoid it.