Timing · 3 min read
How Long ED Medications Last
Onset, effective window and half-life, explained.
- Written by
- SynMale Editorial
- Originally Published
- October 2026
- Last Updated
- October 2026
- Medical Review
- Not yet independently reviewed
Sildenafil and vardenafil: about 4–6 hours. Avanafil: up to about 6 hours. Tadalafil: up to 36 hours. These are windows of responsiveness to stimulation, not continuous erections.